Recent publications

Green GS, Fujita M, Yang HS, Taga M, Cain A, McCabe C, Comandante-Lou N, White CC, Schmidtner AK, Zeng L, Sigalov A, Wang Y, Regev A, Klein HU, Menon V*, Bennett DA*, Habib N*, De Jager PL* (2024) “Cellular communities reveal trajectories of brain ageing and Alzheimer’s disease” Nature 633(8030):634-45.

Paryani F, Kwon JS, Ng CW, Jakubiak K, Madden N, Ofori K, Tang A, Lu H, Xia S, Li J, Mahajan A, Davidson SM, Basile AO, McHugh C, Vonsattel JP, Hickman R, Zody MC, Housman DE, Goldman JE, Yoo AS, Menon V*, Al-Dalahmah O* (2024) “Multi-omic analysis of Huntington’s disease reveals a compensatory astrocyte state” Nature Communications 15(1):6742.

Mares J, Costa AP, Dartora WJ, Wartchow KM, Lazarian A, Bennett DA, Nuriel T, Menon V*, McIntire LBJ* (2024) “Brain and serum lipidomic profiles implicate Lands cycle acyl chain remodeling association with APOE e4 and mild cognitive impairment” Front Aging Neurosci (16):1419253.

Qu W, Lam M, McInvale JJ, Mares JA, Kwon S, Humala N, Mahajan A, Nguyen T, Jakubiak KA, Mun JY, Tedesco TG, Al-Dalahmah O, Hussaini SA, Sproul AA, Siegelin MD, De Jager PL, Canoll P, Menon V*, Hargus G (2024) “Xenografted human iPSC-dervied neurons with the familial Alzheimer’s disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator” Acta Neuropathologica 147(1):107.

Al-Dalahmah O, Lam M, McInvale JJ, Qu W, Nguyen T, Mun JY, Kwon S, Ifediora N, Mahajan A, Humala N, Winters T, Angeles E, Jakubiak KA, Kühn R, Kim YA, De Rosa MC, Doege CA, Paryani F, Flowers X, Dovas A, Mela A, Lu H, DeTure MA, Vonsattel JP, Wszolek ZK, Dickson DW, Kuhlmann T, Zaehres H, Schöler HR, Sproul AA, Siegelin MD, De Jager PL, Goldman JE, Menon V, Canoll P, Hargus G (2024) “Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons” Cell Stem Cell 31(5):676-93.

Chintamen S*, Gaur P*, Vo N, Bradshaw EM, Menon V, Kernie SG (2024) “Distinct microglial transcriptomic signatures within the hippocampus” PLoS One 19(1):e0296280.

Yadav A*, Matson KJE*, Lee D, Alkaslasi MR, Roome RB, Ward ME, Phatnani H, Le Pichon CE, Menon V*, Levine AJ* (2024) “A reproducible signature of cytoskeletal and ALS-related genes in human motoneurons” Neuron 111(23):3742-44.

Cain A, Taga M, McCabe C, Green GS, Hekselman I, White CC, Lee DI, Gaur P, Rozenblatt-Rosen O, Zhang F, Yeger-Lotem E, Bennett DA, Yang HS, Regev A, Menon V*, Habib N*, De Jager PL* (2023) “Multicellular communities are perturbed in the aging human brain and Alzheimer’s disease” Nature Neuroscience 26(7):1267-1280.

Yadav A*, Matson KJE*, Li L, Hua I, Petrescu J, Kang K, Alkaslasi MR, Lee DI, Hasan S, Galuta A, Dedek A, Ameri S, Parnell J, Alshardan MM, Qumqumji FA, Alhamad SM, Wang AP, Poulen G, Lonjon N, Vachiery-Lahaye F, Gaur P, Nalls MA, Yue AQ, Ward ME, Hildrebrand ME, Mery PF, Bourinet E, Bauchet L, Tsai EC, Phatnani H, Le Pichon CE, Menon V*, Levine AJ (2023) “A cellular taxnomy of the adult human spinal cord” Neuron 111(3):328-44.

Luquez T, Gaur P, Kosater IM, Lam M, Lee DI, Mares J, Paryani F, Yadav A, Menon V* (2022) “Cell type-specific changes identified by single-cell transcriptomics in Alzheimer’s disease” Genome Medicine 14(1):136.

Lim RG, Al-Dalahmah O, Wu J, Gold MP, Reidling JC, Tang G, Adam M, Dansu DK, Park HJ, Casaccia P, Miramontes R, Reyes-Ortiz AM, Lau A, Hickman RA, Khan F, Paryani F, Tang A, Ofori K, Miyoshi E, Michael N, McClure N, Flowers XE, Vonsattel JP, Davidson S, Menon V, Swarup V, Fraenkel E, Goldman JE, Thompson LM (2022) “Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation” Nature Communications 13(1):7791.

Nunnelly LF, Campbell M, Lee DI, Dummer P, Gu G, Menon V, Au E (2022) “St18 specifies globus pallidus projection neuron identity in MGE lineage” Nature Communications 13(1):7735.

Russ DE, Cross RBP, Li L, Koch SC, Matson KJE, Yadav A, Alkaslasi MR, Lee DI, Le Pichon CE, Menon V, Levine AJ (2021) “A harmonized atlas of mouse spinal cord cell types and their spatial organization” Nature Communications 12(1):5722.